Opechancanough’s First War

Opechancanough’s First War On Good Friday, 22 March 1622, Opechancanough’s Powhatan Confederacy launched surprise attacks on Virginia’s settlements and killed 347 of the 1,200 colonists. Besieged at Jamestown and unable to plant crops, another 500 died of epidemics and malnutrition that year. The English retaliated with a scorched-earth policy, and destroyed the enemy’s villages and foodstocks during the next two winters. Opechancanough and Governor Francis Wyatt signed a peace agreement in April 1623. The war tipped the balance of military power from the Indians to whites.